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The role several species of yeast and fungi play in various diseases
Dr. William Shaw
Dr. William Shaw, scientist and founder of The Great Plains Laboratory, has been studying for decades the microbial ecology of the GI tract and the role several species of yeast and fungi play in various diseases, including autism, Attention deficit disorder (ADD), Rett's syndrome, Ulcerative colitis, Seizures, Depression, Child Psychosis, Fibromyalgia, Chronic Fatigue Syndrome, Pervasive developmental disorder, Colitis, Schizophrenia, Migraine headache, Alzheimer's disease, SLE, Obsessive compulsive disorder (OCD), Tourette's syndrome, Inflammatory bowel disease and Crohn's disease.
Here are some of his findings.
Microbial Ecology of the GI Tract
"The number of microorganisms in the GI tract approaches the total number of cells in the body. Approximately 500 species of bacteria are present, of which 30-40 species of bacteria predominate, including several species of yeast and fungi.
The greatest number of species are anaerobic or facultative anaerobes. Yeast/fungi and Clostridia species are widely known to accompany the use of broad spectrum antibiotics. Furthermore, recent research indicates that the growth of certain Candida types is markedly stimulated by antibiotic addition to the culture media.
Books like The Yeast Connection and Yeast Syndrome have spread the knowledge about the health effects of Candida to the general public, but are widely ignored by a large segment of the medical community."
His treatment protocol focuses on prolonged doses of the antifungal medications, including Nystatin, Lamasil, Sporanox, Nizoral, Diflucan, Caprylic acid, grapefruit seed extract and garlic extract.
He found that the drugs worked well as long as the patients were taking them. When the drugs were discontinued, the symptoms would reoccur. These are his words:
"I have now detected this same phenomenon in hundreds of other cases. Even after six months of antifungal treatment, there is often a biochemical "rebound" and loss of improvements after discontinuing antifungal therapy. This rebound also occurs after other antifungal drugs as well.
Several explanations are possible for this phenomenon:
Because of one or more defects in the immune system such as IgA deficiency, IgG deficiency, or severe combined immunodeficiency disease (SCID) which are found in most children with autism, the yeast, which are everywhere in our environment including the food we eat, repopulate the intestinal tract very rapidly.
The yeast are very resistant and have not been completely eliminated even after six months of antifungal therapy.
The yeast have genetically transformed some of the human cells that line the intestinal tract so that some of the human cells now contain yeast DNA. These genetically transformed human cells produce both yeast and human products and are somewhat sensitive to antifungal drugs but are not killed by them and produce yeast products whenever antifungal drugs are absent.
Some of the yeast are hidden in recesses of the intestinal tract or in the deeper layers of the mucosa that lines the intestine where they are relatively safe from the drug. Although their numbers are small, they readily repopulate the intestine after antifungals are stopped.
In addition to the immune system taking inventory of its own cells, it seems increasingly likely that the immune system also takes an inventory of bacteria and yeast cells present in the intestinal tract soon after birth. This inventory is performed by a group of cells called the CD5+ B-cells, which are among the very first immunological cells to appear in the developing embryo and appear to play a role in tolerance to intestinal microorganisms in postnatal life. These cells may play a role in regulating the secretion of IgA, the antibody class that is secreted into the intestinal tract and which may select which microorganisms are tolerated in the intestinal tract. Furthermore, the eradication of normal flora especially when antibiotics are administered repetitively during infancy may cause the CD5+ cells to reject these normal organisms at a later age. Any cells that are on this early inventory may be awarded immune tolerance and will not be attacked later on by the immune system. Either antibiotic use in infancy or yeast infection of the mother during pregnancy may result in later immune tolerance to yeast.
Not surprisingly, neurofibrillary tangles similar to those found in the brains of Alzheimer’s victims have also been reported in the brain of an autistic person at autopsy. It has been reported that frequent urinary tract infections and high amounts of circulating immune complexes are associated with more severe Alzheimer disease. The use of antibiotics to treat urinary tract infections would of course lead to yeast overgrowth of the gastrointestinal tract.
Elevation of yeast metabolites are found in many of the same disorders and are even more common in autism, SLE, Alzheimer’s disease, fibromyalgia, attention deficit hyperactivity, and chronic fatigue syndrome.
The finding of pentosidine in the neurofibrillary tangles of Alzheimer’s brains and its absence from normal areas of the brain may indicate a direct role of a yeast byproduct in accelerating the normal aging process. Tartaric acid from yeast overgrowth has a direct toxic effect on muscles and is an inhibitor of a key Krebs cycle enzyme that supplies raw materials for gluconeogenesis and offers an explanation for many of the symptoms of fibromyalgia.
Interestingly, I have found that tartaric acid and/or other yeast byproducts are also elevated in urine samples of adults with the disorder fibromyalgia, a debilitating disease associated with muscle and joint pain, depression, foggy thinking, and chronic fatigue. (Dr. Kevorkian has assisted in the suicide of two people with this disorder, which is tragic since a simple antiyeast treatment may help relieve the symptoms of this disorder.)
Richard Jaeckle, MD, a psychiatrist and allergist in Dallas, Texas has treated a number of psychotic individuals using antifungal therapy and finds that psychotic patients with elevated CPK, uric acid and white cell counts may respond favorably to antifungal treatment. Patients with psychotic behavior may have gastrointestinal overgrowth of both yeast and Clostridia."
"The toxic yeast products were just discovered, but as knowledge of them increases, acceptance of the yeast-related illnesses will increase.
As the philosopher Schopenhauer said, 'All truth goes through three stages. First, it is ridiculed. Then, it is violently opposed. Finally, it is accepted as self-evident.' Within five years, people who ignore the importance of yeast-related illness will be in the same camp with those in the Flat-Earth Society."
While their work is extremely exciting, they do not warn of the dangers of long term usage of some of these potentially highly toxic drugs, such as liver damage and/or failure. And even Dr. Shaw concedes that the yeast overgrowth reoccurs after treatment is stopped.
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December 19,2004
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